Ozempic Vs Phentermine — Which is Better for Weight Loss?

Ozempic Vs Phentermine


In Australia, about 2 out of 3 people are obese, counting up to 12.5 million adults.

That’s millions of people not living their best lives as being overweight or obese comes with, if not caused by, medical conditions.

So if you have a weight problem, you probably aren’t able to fully enjoy your passions and do your best at work or school. And the worst part is that it can make you feel less useful and confident, leading to mental health disturbances.

Indeed being overweight or obese can limit you significantly. So if you want to experience life better, you need to become healthier and achieve an ideal weight.

The good news is that there are now medications that you may take to help you start a new journey to fitness.

Two of the Australian-approved weight loss medications are Ozempic and Phentermine.

But while these medications are effective in helping patients lose weight, some people will benefit from one more than the other.

So in this article, we will address their comparisons so you can assess for yourself which one you might have to use to resolve your weight problem.

You’ll learn about:

  • What these drugs are,
  • How they work, and
  • Which one is better?

What is Ozempic? 

Ozempic is a prescription injectable weight loss medication with the generic name Semaglutide. This medicine is used in conjunction with diet and exercise.

It aims to improve blood sugar levels in adult patients with type 2 diabetes and lower the risk of serious cardiovascular events.

It is effective in decreasing the possibility of a heart attack, stroke or death in persons with type 2 diabetes who already have heart disease.

What is Phentermine?

Phentermine is an oral prescription appetite suppressant with the generic name Adipex-P, Lomira.

It can aid in weight loss by lowering your appetite or making you feel not hungry for longer. 

Phentermine, like other weight-loss prescription medications, is meant to be used as part of a comprehensive weight-loss regimen.

It is indicated for people who are obese, and who have failed to properly lose weight with diet and exercise alone. So this medicine is not for people who want to lose just a few pounds.

How do they work?

Ozempic works by imitating the hormone glucagon-like peptide-1 (GLP-1). GLP-1 regulates digestion and appetite, making you feel full and causing you to eat fewer calories.

Ozempic activates your pancreas to produce insulin after a meal and prevents a hormone that enables your liver to generate sugar.

It also delays the rate at which food exits your stomach (a process known as gastric emptying), leading you to feel fuller for longer. However, this can have some unfavourable side effects, such as nausea and vomiting.

While other medicines in their class may need to be taken on a daily basis, Ozempic just needs to be taken once a week because it works in your system for a longer amount of time.

In contrast to Ozempic, Phentermine possesses stimulant properties. It acts as a stimulant to your central nervous system, therefore altering brain chemicals to make you feel full.

You'll normally take it 1-2 hours after having your morning meal, and it will assist to suppress your hunger throughout the day. Consuming one 30 mg pill daily, for example, has been shown to reduce hunger for 12 to 14 hours.

How fast do they work?

how fast do they work


Once Ozempic is approved for you, you'll probably need to gradually raise your dosage until you reach the intended dose to observe the most weight reduction (2.4 mg once weekly). During the clinical studies, for example, dose modifications were done every 4 weeks or so as long as subjects tolerated them.

However, even before you reach the optimum dose, you may notice some weight loss.

One of the phase 3 trials examined weight loss prior to the full dose at 20 weeks and discovered that the majority of patients were able to lose weight during this time.

Over the next 48 weeks of the trial, participants lost extra weight.

Currently, phentermine is only approved for brief use, which would typically be 12 weeks. During this time, you should anticipate dropping at least 5% of your initial body weight.

After a few weeks, you may acquire resistance to the medicine and find that it no longer works for you. If this occurs, your physician would most likely require you to discontinue use.

Which one is better, Ozempic or Phentermine?

Ozempic is currently not authorized for weight reduction in people who do not have diabetes.

However, in the majority of phase 3 studies conducted for this purpose, study data revealed a 15% to 18% weight reduction in individuals who've been overweight or obese. The duration of treatment across all phase 3 investigations was 68 weeks.

A meta-analysis of trials ranging from 2 to 24 weeks of phentermine medication (an average of 13 weeks) revealed a mean overall weight loss of roughly 6.3 kg.

People who took phentermine lost an extra 3.6 kg of body weight as compared to those who took a placebo.

Although phentermine is only intended for short-term usage, some doctors may give it off-label for prolonged periods of time.

While there aren't many protracted safety and efficacy trials with phentermine, early recognition research indicated that those who took the prescription for more than three months lost more weight without an increased risk of heart disease or mortality.

Which is costlier?

Ozempic is now accessible exclusively as a brand-name prescription, which means it will be more expensive.

And not all weight loss drugs may be covered by some insurance plans. According to 2019 research, 68 per cent of these prescriptions were paid for out of patients’ pockets, which means they were not covered by insurance.

However, you may be able to use manufacturer savings cards to make the drug more reasonable if you are eligible to use Ozpemic.

On the other hand, Phentermine is available as a lower-cost generic, making it more affordable. With specific coupons, you can even acquire 30 phentermine 37.5 mg tablets for as little as $16.

So which one should I take?

Phentermine is amongst the most regularly utilised weight loss drugs. It is less costly, but it is only allowed for short-term use.

Ozempic hasn't been here as long, but clinical trials have yielded some promising results. Once approved, you may have to pay out of pocket.

Still, there may be additional methods to make it more accessible, like getting your medication online and avoiding more overhead costs of going to a clinic or pharmacy.